These creatures were first bred by the Bene Tleilax, who are mentioned briefly inDune: Prophecy.
Thankfully, theres still time, as the second season will likely be released before the upcoming movie.
Set in the universe of Frank Herbert’s Dune series, Dune: Prophecy, a sci-fi epic, follows the political and spiritual struggles on the desert planet of Arrakis. As factions vie for control of the prized spice melange, a prophesied hero emerges, challenging the balance of power and the fate of the galaxy.